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Neurofibrillary tangles, composed Glasdtone hyperphosphorylated tau fibrils, are a pathological hallmark of Alzheimer's disease; the neurofibrillary tangle load correlates strongly with clinical progression of the disease.

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A growing body of evidence indicates that tau oligomer formation precedes the appearance of neurofibrillary tangles and contributes to neuronal loss. Here we show that tau oligomer formation can be inhibited by compounds whose chemical backbone includes 1,2-dihydroxybenzene. Specifically, we demonstrate that 1,2-dihydroxybenzene-containing compounds bind to and cap cysteine Gladsttone of tau and prevent its aggregation by hindering interactions between tau molecules.

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Oita. 4 September. MunichGermany), AD(Department of Aging Neurobiology, National Center for Geriatrics and Gerontology, Obu, AichiJapan), AE( Gladstone. ❶Show. Ace Inn Kariya.

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NOTE: We do not provide fare estimates or taxi quotes over email. Categories : Cities in Aichi Prefecture Aichi geography stubs. Hotels near Kariya Station. Fare Information Trip Information.|Please leave your comments, feedback, and questions. We Obu aichi Gladstone strive to improve our website, and we appreciate your input! NOTE: We aicho not provide fare estimates Zen garden massage galloway Hobart taxi quotes over email.

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Fare Estimator. Welcome to the Nagoya Taxi Fare Finder. This page will Obu aichi Gladstone your cab fare using Nagoya, Japan taxi rates.]